Malignant histiocytosis: a specific t(2;5)(p23;q35) translocation? Review of the literature.

نویسندگان

  • E Benz-Lemoine
  • A Brizard
  • J L Huret
  • P Babin
  • F Guilhot
  • D Couet
  • J Tanzer
چکیده

In this paper, the investigators report a well documented case of malignant histiocytosis (MH) with a t(2;5)(p23;q35) translocation. A breakpoint in 5q35 appears to be specific, either for the disease or for a subclass of the disease. Additional cases of MH with cytogenetics are needed. This will help to determine if one class of MH or several subclasses can be defined by cytogenetic anomaly(ies).

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A novel translocation, t(2;5)(p23;q35), in childhood phagocytic large T-cell lymphoma mimicking malignant histiocytosis.

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We report the molecular, cytogenetic, and immunologic characterization of three hematologic malignancies that contained characteristic t(2;5) chromosomal translocations. The clinicopathologic features in all three cases fit the disease spectrum of so-called malignant histiocytosis (MH). All cases expressed activation antigens including Ki-1 (CD 30), but no lineage-restricted pattern of cellular...

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عنوان ژورنال:
  • Blood

دوره 72 3  شماره 

صفحات  -

تاریخ انتشار 1988